Santa Cruz is too busy and too big for Frampton and I'm not sure how Frampton is going to get inside to get his punches off because Santa Cruz must have a big reach advantage (as would almost anyone in that division against Frampton).
I can see a couple of flash knockdowns against Frampton, but he won't be particularly hurt and it should go the distance.
And as the fight goes on, Frampton will have to take more risks, which should make for an entertaining fight.