I'll be rooting for Fury, but he's up against it.

Wilder will have home country advantage. The referee (possibly Jack Reiss, who is America's Ian John-Lewis) and the judges will be on his side, especially since he's co-managed by Al Haymon. Fury cannot win a decision unless he completely dominates, and after his long layoff and serious personal problems, he will not be back to his best.

Because of the massive weight gain followed by a massive weight loss, Fury will be weakened, much like Jim Jeffries was when he fought Jack Johnson. People who go on crash diets lose muscle along with the fat, and it takes months and plenty of exercise before their full strength returns. So I don't think Fury is strong enough to knock out Wilder, but I do hope I'm wrong.

My prediction:

1) There about a 75% chance Wilder will KO Fury, probably in the later rounds but possibly early.
2) There is about a 25% chance that Fury lasts the distance and outboxes Wilder, but not by a wide enough margin to win with Wilder and Haymon's home judges. Wilder will win by gift decision.
3) There is close to a ZERO chance of Fury winning by KO/TKO, because he's not strong enough yet and because the American referee will protect Wilder (especially if it's the notoriously dodgy Jack Reiss).