Mosley's speed would be way too much for Hatton. It wouldn't even be close.
Mosley could take one hell of a shot so I see Hatton trying to press hader and harder and gassing himself. Whereas Mosley could go the 12 rounds at a consistent pace.
TKO ref stoppage in a one sided fight.

Same with Margarito. I am not sold on Margarito yet. I've always said I think his fans want him to be more of a threat than he actually is. Because he hasn't really done anything yet, he's this great hope in the shadows. He's not quick enough for Shane. And his punches are much too looping that even if he does land, someone like Shane will see them coming and be able to roll the punches at least a littleand avoid too much damage. UD for Mosley.

Of those three, Cotto would be the closest fight to me.
I still say Mosley's quicker hands should win him this fight. But Cotto's vicious body attacks just might be able to wear him down for the later rounds. Because I don't think Shane would knock him out, it'd be a grueling 12 rounds for him.
I say Cotto presses hard near the end but too little too late. Mosley in a closer decision.