Whilst I agree that Mayweather is indeed one of the fittest fighters ever to enter a ring, I have to point out that Floyd intelligently monitors his punch output. Some rounds he will punch as little as possible, so it is very seldom that he is ever fatigued.
Calzaghe on the other hand is a volume puncher - a real worker. He throws as many shots as is possible, so obviously he will be fatigued. When a fighter enters with the mindset that he is going to throw as much as he is able he is going to use all of his fuel regardless of how much he has, where as Floyd enters and only uses what he needs.
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