There are plenty of bigger punchers then Margarito including Mayorga among them. Margarito isn't a huge puncher, but he connects a lot against guys who aren't really good defensively or move a lot. Mosley does neither extraordinarily well so I think he will just be outpunched, but at least Margarito will be throwing real punches that are designed to do damage unlike Calzaghe.
I just don't think Mosley has the know how to effectively deal with punchers/brawlers. IMO he slugged it out way too much with Vargas when other guys with his athletic ability like Mayweather are much more adept at fighting the bigger guys. Mosley has always had troubles with it.
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