Fresh Prince of Bel Air: "YOU ARE NOT MY FATHER!" scene with Uncle Phil and Will.

Full House: "Goodbye Uncle Jesse" scene.

Growing Pains: Last episode when they finally moved out of the house.

Friends: When Joey and Chandler share their last hug to solidify their bromance.

DragonBall Z: Either when Goku sacrificed himself against Cell to save Earth or when Vegeta finally told his son he loved him.