Manny Pacquiao...Parkinsons or Alzheimers after fighting JMM?

[Addicted to_boxing]

Saying Pac has Parkinsons or Alzheimers after fighting JMM may be silly ( I agree ) . Assuming that Pac will come back and mow down the competition is assinine.

Only safe opponents that will generate cash flow are Hatton, Bradley and Cotto.

[TysonBomb]

I'm a student and by no means an authority, but I can tell you that from what I've seen, Pac isn't displaying any symptoms of any kind of neurological degenerative disorders like Parkinson's or Alzheimers

The physicians who released these statements should know better than to make diagnoses based on what they see on TV. Both of these diseases are progressive and take time to fully manifest.

I haven't seen any kind of tremors or Pac showing any kind of memory problems to suggest any kind of evidence for either disease.

Besides if you want to get into the biochemistry of both disorders, they are kind of at the opposite ends of the spectrum.

In Parkinson's, there is a dopamine deficiency and eventually the dopaminergic receptors themselves start to degrade. With the decrease of dopamine, the cholinergic system starts to take over. The imbalance between achetylcholine and dopamine is why these involuntary tremors at rest occur.

In Alzheimers the cholinergic system is effected first, resulting in a decrease in achetylcholine in parts of the brain. That's why anti acetylcholinesterase agents are administered initally.