The best way is to avoid even taking a shot!

Keep an eye on What your opponent is doing. Most KO's come from when a fighter is so engrossed in throwing that a shot comes in that he didn't see and then he's on his ass. Look at Fury and Prices last 2 fights.

Eubank used to ride them, turning his head as it was coming to take the sting out. Thats about as good as you can do. People like Air Khan could have Mike Tysons neck transplanted on to them but they will still have shit punch resistance. It must have something to do with the fluid around the brain itself, maybe a tough man will have more so it acts as a shock absorber, or he has less so it doesn't rattle around as much? Who knows but iv seen fighters with weak looking necks that take good shots.