Good luck hitting somebody with that. It may work in MMA bouts because those dummies like to get hit- it seems, because they don't get out of the way of much. He telegraphs the hell out of that punch, winding up and throwing it like a baseball. The thing about throwing a right hand (or, for a southpaw, the left) is that it comes right from the shoulder, even if you are throwing it with a loop or hook in it.
In boxing you'd have a real hard time landing that punch, overhand like that, on a legal part of the glove, on the knuckles. When I was about 15 I was sparring with a guy that got frustrated because he couldn't hit me with a jab or a right hand, so he threw that desparation over hand punch he was talking about. I got under it, more or less...His glove didn't hit me but his wrist hit me on top of the head and shook me pretty good for a second.
Tyson slips on his legs. You have to slip on your feet and legs to be able to punch back. If you just bend at the waist, you'll be off kilter and unable to punch back. Especially if you bend to the side.