Personally, I'd find it very hard to see Hatton doing anything but getting a lesson by Mayweather. Hatton is a competent fighter at world level, but he is not really much of a technical fighter, more of a heart, guts and blood n thunder kind of fighter, but he would need to hit Mayweather flush with 3 or 4 lucky shots in the same round to have a realistic shot at winning. Despite Hatton's workrate, I think the Mayweather would stay at distance and pick him off.

Also Hatton only just beat Collazo in a very tight affair at welterweight, so I think he'll be staying at Light-Welter for the forseeable future, as his power is really more impressive there than at welter.