Should be one hell of a fight. I'd say Cotto has to be the starting favourite, he could well outbox Margarito, but I will be rooting for Tony.

If he can keep his punch output high for all 12 rounds it's possible he could pull this off.

I don't think either will be able to stop the other so it should be a 12 round war.

EDIT

Thinking about it though, isn't Cotto like only 5 ft 7?

I'm guessing Margarito must be around 6 ft so it could be possible that he can keep Cotto at the end of his jab for much of the fight.

Actually I think Margarito could well be the favourite once they get in the ring. He's a big lad after all.