I don't think the size difference (apart from Hoye's height) would be a big issue. I don't know how Kessler makes 168. He's the biggest super middle I've seen. The difference between him and Mundine in the ring was amazing and Mundine's played an endurance sport (rugby league) at an elite level at around 180 pounds.

If Woods stopped Hoye I don't think Kessler will have too much trouble with him.