I don't think a standard rule should exist. Leave it up to the ref with an understanding that if a knockdown happens late in a fight, just be very careful regarding letting the fight go on.
Almost all permanent injuries / Deaths occur in the later rounds, when a fighter is exhausted and less able to recover and more prone to get really nailed.
Early in a fight, many knockdowns are not as severe, and if they still have their faculties, the three knockdown rule could impede a fighter who is simply cold and fighting with nervous energy from getting into the fight.
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