Mayweather would never go to the ropes like he does if he was in the ring with Margarito. Margarito's footwork isn't good enough to consistently cut the ring off. Taeth is right, look at the Baldomir fight. That's exactly what the Margarito fight would look like. Also, Floyd didn't give up the body to Hatton like he did versus De La Hoya, I really doubt he would give it to Margarito.

Just look at what trouble Margarito had when Williams was moving. Williams has nowhere near the footwork of Mayweather, I think it would be 120-108 it's just a terrible, terrible style matchup for Margarito.

Cotto is different, that's a great fight and as close to a pick em as you will get with Mayweather. A great fight between the two best fighters in the world right now imo.