As good as Margos chin is, Tito had fought a few guys like that in his day and their chin was never the same after fighting Tito.

Tito has one punch concussive power while Cotto has hard heavy thudding punches do are better suited for body punching.

If Santos was able to hurt Margo, Tito knocks him out for sure.

Margaritos lack of defence and speed would be the big difference.