In the comic there are things called HULKBUSTERS that are huge robotic suits manned in the same way that Starks-IronMan are. Tony has one of his own in fact. The first one that was made.

"The Hulkbuster armor is a heavy-duty exo-frame (an add-on to the Mk. XI Modular Armor) designed for maximum strength amplification at the cost of reduced versatility and mobility. As its name suggests, it was specifically designed for hand-to-hand combat with the rampaging Hulk. The armor was rated with a lift (press) capacity of 175 tons. During its maiden run, the armor enabled Stark to hold his own in sustained physical combat with the Hulk. In subsequent battles with the Hulk, however, Stark has declined to utilize this armor, so it is unclear whether it is indeed capable of defeating the Hulk." -- Wikipedia