It depends on how each fighter handles it.

Cotto had a lot of success in his fight, but still got beaten after seemingly having the fight his way at the beginning. He did have success in that fight and has something to build on for the future and can probably see the corrections he has to make.

Pavlik had no success and was never in his fight. If he chalks it to just a terrible night, he could rebound fine. If he concentrates on how badly he was beaten, and tries to find out what he did wrong, he will never find an answer for it.

Both of them have a huge task ahead of them. Both of them have a huge amount of pride. They both had incredible confidence that got shattered. Cotto will always question his own durability and Pavlik will always question his skill level.