Tony Rice was sick. So was Ricky Waters. Shortly thereafter Reggie Brooks and Jerome Bettis came through. Brooks didn't do anything in the NFL but he was a warrior at ND:

http://www.youtube.com/watch?v=rX5dk3XvzYs

My all time favorite run though was this one from Greg Jones:

http://www.youtube.com/watch?v=WKknaWEln9w