Marquez sure had some difficulties hitting Pacquiao at times, same with Oscar. Pacquiao isn't the fighter some people remember him to be 5 years ago. Also Mayweather isn't Marquez, while Marquez is willing to stand and trade, MAyweather isn't usually and he doesn't have the greatest track record against southpaws even though he is undefeated Sanders, Corley, and Judah all hit him way more than they should have.
Bookmarks