I don't think anything will nullify his output, I seen one of Lacy's really good shots land on Joe's chin and it had no effect. It's really hard to stop someone who throws punches in such volume and won't go down, always coming forward never running out of gas and can step back and technically box you at the same time. Calzaghe doesn't fight the same in every fight, that was just the forumla he used for Lacy. Who knows how he'd fight Hopkins, but either way JC is too versatile for Hopkins.