I think that comfort idea may be the real deciding issue -- if you feel more awkward on one side it probably isn't a good choice.
I feel differently about "strongest hand as jab" and actually like doing that (if I were deciding again) as I mentioned above. Your rear-power hand receives a LOT more help from your body and legs, and you will use your front-jab hand 2-3 times (or more) for every rear hand punch.
Using your best hand for that seems to make sense, but I am working from logic (not experience) and have no real evidence that this is correct.
I actually made this conscious decision when training for knife defense -- i.e., to hold my own knife in the Left/Jab hand and generally use a right hand boxer's stance.
Difference in knife work is that ANY decent hit can do damage or win a fight (i.e., stop a criminal attack) and you 'other hand' isn't nearly as much use (there's checking, blocking, defense etc but the second hand is a small assist compared to boxing.)
I still believe that anyone who CAN COMFORTABLE start out left handed should -- since it is generally thought a left-hander has an advantage over a right-hander (all else being equal). Another reason I went to left hand for knife -- I practice this constantly (as Southpaw boxers do) so I have an experience advantage when facing a 'right-hander' who doesn't know the intracies of the mirror image position as well.
Note: When left meets right, they technically have EXACTLY the same advantages and disadvantages due to the position, the difference comes with this experience and familiarity, e.g., knowing more tricks and seeing the relationships better.
If I had it to do over I would probably start out left handed. Of course, that would screw up my training for using a knife left handed.
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HerbM
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