I use the right hook every so often....it gives you a ton more power and is a change-up for the right cross or right uppercut.
Only use it when you have your opponent hurt or on the ropes. You can use it on the body effectively a la George Foreman.
Foreman and Tyson and more recently Miguel Cotto have used the right hook as orthodox fighters with great success. It's a tough punch to land and it's easily countered and can put you in bad situations HOWEVER it's extremely powerful when you throw it correctly and it can definently end fights.
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