Spence is too young and too big. I dont think it would be some pretty clinic like most others. Spence is already has 4.5 inches on Manny, so its easy for him to make weight and then rehydrate up to 160 or so, negate manny's power (which isn't great at welter) and then maul him by walking him down behind the jabs and throw counters with him and rake the body when he's on top of him. (a replay of the brook fight--you can land shots on Spence, but if you cant hurt him, hes gonna have all night to walk you down. All the better if your a shade slower, a bit smaller, or your legs are going/ have gone)