i'm from rochester, where 3 out of every 4 fighters are southpaw or switch hitters, including myself, and what i've learned very fast is that a lot of the "tricks" that people have developed for fighting southpaws are so commonly tried that they are becoming dated and easy to ignore for us. i dont even wanna get into how many times ive had people come out assuming their right hand leads are going to be more useful than my left hand leads, or that they will be able to get their foot outside of my lead foot at will. ha. the best way to deal with it is not worry so much about the stance of the fighter but the other factors of fighting i.e. aggression, skill, power, speed, slickness...as far as would a cross guard work as a southpaw, anything works as a southpaw, its up to you to make it work by finding the range you need to make the shots successful