3 inches below the ear where the jugular and aorta cross over each other disrupts the flow in and the flow out of blood pressure to the brain, total lights out.
Hard shot with boxing gloves better to glance off the side.
More for open hand or open fingered gloves and styles ,strike with the mid finger knuckles using the oppositions extended arm as a runway into the neck .
Wrist, elbow ,or forearm arm does the trick entering in from other positions ,the back of the heel on the axe kick.