Clottey doesn't have the work rate, stamina, or the power to really bother Cotto from what I've seen, although Cotto's chin isn't exactly made of steel. Clottey's best chance IMO is to use his defense, try to keep Cotto on the outside, and box his way to a decision. I think it'll be close-ish (maybe 116-112/117-111), but Cotto will win.