I'm picking Cotto to win this.
Manny is truly a phenom, but I think a prime and focused Cotto will be too much for him at 145. Miguel won't be as careless as Hatton was, and he won't look as sluggish and drained as Oscar did.
He has underrated hand-speed, a pretty tight defence and can be a murderous body puncher too.
It won't be easy, but I'm going with Cotto by 10th round stoppage.