When has Mayweather ever weighed 152-154? The most he ever weighed in at was 150 for Oscar, and he actually lost a pound come fight night by unofficial reports (He wanted to weigh-in, but Oscar didn't want to show how much bigger he was(which was reportedly 163ish). I have never seen Mayweather fight at more than 6 pounds heavier than the weigh-in. That means there will be no significant weight difference between him and Marquez, Mayweather hasn't had to dehydrate for a weigh-in since fighting at 135. Since then he has always weighed in, within 3 pounds of what he entered the ring at.
Besides in terms of weight, its only a disadvantage for Mayweather weigh more. He wants to be as quick as possible because thats where his advantage lies, and Marquez being naturally smaller actually has an advantage in weighing less because it will give him better speed. Weight helps with 2 things 1) Strength 2) Power. Mayweather won't hit harder than Marquez at 143 because he doesn't really sink into his shots, and he doesn't physically impose himself on guys so his strength won't play a huge factor in the fight.
What will is his talent. These are two p4p greats, and this fight will be decided on who is the better boxer, and IMO Mayweather isn't vastly superior, but clearly superior, and too much quicker.
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