There is some good advice on this thread so far. You could certainly go the VD route - that's the most guaranteed way to instant success. Yeah, you need to be confident or at least act that way. That's a must, but it's not always easy to achieve, so I'll give a tip about staying relaxed and staying confident.

Rule 1: Know your game an know your target. If you are really good looking, very posh, and carry a stash of coke or e, you can probably get laid anytime a a club. If you don't fit his description, stick with bars and pubs that draw women. Karaoeke nights are good, as long and you don't sing. It's just that they draw out women.

Rule 2: Don't go out with the express intention of hooking up for meeting anybody. Go out with your friend with the understanding that you will have fun and the night will be a success if you just get a buzz and have laughs with your buddies. It takes all the pressure off and lets you just be yourself. This is really key. Have a good wingman or wingmen.

Rule 3: Don't worry about closing the deal that night. This is not to say that you won't close the deal, but if you thinking about trying to make it happen that night, it probably won't, unless you go the VD route. Women can smell desperation and an agenda. The only way you will hook up that night if you are scheming for it to happen that night is if she is just as desperate as you. It happens, but it's unlikely.

Rule 4: Don't talk like a big shot. Be quietly confident - ask more questions and listen more than you talk. Don't brag. I've seen guys who were totally in fuck up by talking to much and trying to impress too much. Let the pussy come to you. If you don't get laid that night, you might get a date and get a blowjob next weekend.

Rule 5: If you are set on just getting laid, target the second or third best looking girl in the group. The hottest ones get hit on all the time and they are immune to anybody that doesn't have an A game. I'm not saying go ugly (you can do that if you want), but the girl who is a 7 but has friends who are 9's is used to watching the hotter friends get the guys. Target the still attract, second tier friend and ignore the super hottie. This makes them feel special, and they are more likely to desperate to fuck you that night.

Those are my rules. They worked for me. They got me laid in bars when I was single, and I met my current wifey this way - when I was just getting back into the game after a divorce. Following rule three has the best change of eventually getting you another girlfriend. Rule 5 will get you laid and you're more likely to beer goggle.

A few more important tips - talk to women, they will not come to you normally. Don't wait until 15 minutes before last call. If you do that, you seem really pathetic. Start your work earlier, give yourself some time. Lastly, practice. Who gives a shit if you get shot down? Like anything else, you'll only get better if you learn from your mistakes and keep trying.

Hope that helps.