I think it depends on the context of the fighters career.
The old question being: A glass with water at halfway point. Is the glass half full or is it half empty? The answer to the question is if the water is being consumed the glass is half empty. If the glass is being filled it is half full. (not whether you an optimist or pessimist) A fighter beginning his career has losses then it can easily be viewed as part of the learning process. A fighter with a long career and then starts losing... well... it might just be time to put away the gloves.
Of course there are going to be other variables in a fighters career that will contribute to the decision making process about retiring. In the case of De La Hoya, he had a promising career to look forward to as a promoter. It looks like Hatton is at a very similar crossroads in his career and is contemplating the same question. Other fighters like Roberto Duran may not have the same questions to answer in order to make a decision about retiring. Each fighter is going to have a unique set of circumstances.
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