For me the single hardest shot I ever saw was the right hand from Shavers that put Holmes on the ground. I still don't know how Larry got up, and then to go on and win the fight was even more amazing.
Some honorable mention shots:
1) Roy's body shot stoppage of Virgil Hill. Cracked vertebrae!!!
2) Manny's ko shot on Hatton. Sounded like a shotgun blast and ruined Hattons career.
3) Sergio Martinez ko of Paul Williams. Pretty much the same as Manny's ko of Hatton.
4) Sam Peter destroying Jeremy Williams
5) Lennox first big right in Ruddock.
6) Douglas uppercut of Tyson
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